CR programmes are effective in improving medication adherence by an overall effect size of 14 % with high study heterogeneity. This systematic review has shown that CR programmes with longer follow up durations (≥12-months and longer) delivered face to face combined with remote modes of delivery provided in health facility settings led by a pharmacist showed an overall effect size increase of medication adherence ranging from 18 % to 34 %. Our findings were supported by a study which showed that face to face mode of interventions delivered by a pharmacist that targeted individual patients/family focus provided in health care clinic were more  effective than delivering through other modes of delivery, or by other health professionals which targeted health care providers/health systems or in a home setting, respectively.